Traveler’s diarrhea is defined as having at least three episodes of diarrhea (loose, watery stools) in a 24-hour period during travel abroad. It’s often caused by consuming contaminated food or water. Or it may be caused by consuming water that contains different bacteria than what your body is used to at home. Pneumocystis pneumonia is a lung infection caused by the fungus Pneumocystis jirovecii. This infection is more likely to affect people who have a weakened immune system, such as those with HIV or AIDS.
How should I use sulfamethoxazole and trimethoprim?
- A skin rash may be followed by a more severe reaction, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, AFND, AGEP, hepatic necrosis, or serious blood disorders (see PRECAUTIONS and ADVERSE REACTIONS).
- Evaluation for hyponatremia and appropriate correction is necessary in symptomatic patients to prevent life-threatening complications.
- Patients should be counseled that antibacterial drugs including Bactrim (sulfamethoxazole and trimethoprim) tablets should only be used to treat bacterial infections.
- The generic is considered to be as safe and effective as the original drug.
- Alternatively, their doctor may prescribe one tablet of Bactrim DS (800 mg/160 mg) taken every 6 hours for 14–21 days.
In the absence of such data, local epidemiology and susceptibility patterns may contribute to empiric selection of therapy. Prescribing clinicians, including nurse practitioners, primary care providers, physician assistants, and internists who prescribe trimethoprim/sulfamethoxazole (TMP-SMX), should be familiar with ints indications and adverse effects. Difficile produces toxins A and B which contribute to https://sober-home.org/molly-uses-effects-risks/ the development of CDAD. Difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. The usual adult dosage in the treatment of urinary tract infections is 1 BACTRIM DS (double strength) tablet or 2 BACTRIM tablets every 12 hours for 10 to 14 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.
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Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. In this case, the recommended dosage of Bactrim is one 800 mg/160 mg tablet or two 400 mg/80 mg tablets. Bactrim (sulfamethoxazole/trimethoprim) is a brand-name drug that’s prescribed for certain infections.
Sulfamethoxazole and trimethoprim
Trimethoprim is an antifolate antibiotic that works by inhibiting an enzyme, resulting in bacteria’s inability to make DNA and survive. Sulfamethoxazole and trimethoprim are combined because they are complementary and have a greater effect when used together. BACTRIM may inhibit the hepatic metabolism of phenytoin (a CYP2C9 substrate). BACTRIM, given at a common clinical dosage, increased the phenytoin half-life by 39% and decreased the phenytoin metabolic clearance rate by 27%. Treatment failure and excess mortality were observed when BACTRIM was used concomitantly with leucovorin for the treatment of HIV positive patients with P. jiroveciipneumonia in a randomized placebo-controlled trial. 4Avoid coadministration of BACTRIM and leucovorin during treatment of P. jiroveciipneumonia.
Get medical help right away if you get sunburned or have skin blisters/redness. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, can i attend a meeting online or by phone and herbal products). If you notice other effects not listed above, contact your doctor or pharmacist. Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection.
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Increased sulfamethoxazole blood levels may occur in patients who are also receiving indomethacin. Your doctor will work with you to determine the appropriate dosage of trimethoprim-sulfamethoxazole based on your infection, its severity, and your general health. Antibiotics, including trimethoprim-sulfamethoxazole, don’t work for viral infections such as the common cold and influenza. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. If you have trouble swallowing tablets, see this article for tips on how to take this form of medication.
To find out how often side effects occurred in clinical trials, see the prescribing information for Bactrim. If you have side effects that are bothersome or don’t go away, talk with your doctor. They can recommend ways to manage any side effects you have or may suggest a different medication. Here are some frequently asked questions about the drugs’ side effects and their answers.
This medicine is available only with your doctor’s prescription. Mixed medicine must be used within 2 to 6 hours depending on the amount of diluent in the mixture. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it. As with all medications, the cost of Bactrim and Bactrim DS can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use. Bactrim and Bactrim DS can interact with several other medications.
But some people may have food sensitivities or allergies that can worsen certain side effects of Bactrim, such as abdominal pain. In that case, you may want to avoid the foods that worsen these side effects for you. Bactrim is not safe to take during pregnancy or while breastfeeding. If you’re pregnant or breastfeeding, or planning to become pregnant or to breastfeed, talk with your doctor before starting Bactrim treatment. Talk with your doctor to determine whether it’s safe for you to consume alcohol during Bactrim treatment. For this purpose, Bactrim is typically taken twice per day for 3 consecutive days each week.
If you stop taking this medicine too soon, your symptoms may return. Signs of acute overdosage with trimethoprim include nausea, vomiting, dizziness, headache, mental depression, confusion and bone marrow depression. Because sulfamethoxazole and trimethoprim may interfere with folic acid metabolism, BACTRIM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Bactrim is available in tablets in two strengths; 400 mg sulfamethoxazole and 80 mg trimethoprim and the “DS” form which means double strength, 800 mg sulfamethoxazole and 160 mg trimethoprim. Patients should follow their doctor’s instructions and take all of the Bactrim prescribed. Patients allergic to sulfa compounds should not take Bactrim.
This is not a complete list of side effects and others may occur. Doctors may not recommend Bactrim or Bactrim DS while breastfeeding, especially if your child is younger than 2 months old or has certain medical conditions. Bactrim and Bactrim DS should not be taken during pregnancy.
Approximately 70% of sulfamethoxazole and 44% of trimethoprim are bound to plasma proteins. The presence of 10 mg percent sulfamethoxazole in plasma decreases the protein binding of trimethoprim by an insignificant degree; trimethoprim does not influence the protein binding of sulfamethoxazole. The trimethoprim component of BACTRIM has been noted to impair phenylalanine metabolism, but this is of no significance in phenylketonuric patients on appropriate dietary restriction. BACTRIM-induced thrombocytopenia may be an immune-mediated disorder. Severe cases of thrombocytopenia that are fatal or life threatening have been reported.
This includes prescription and over-the-counter medicines, vitamins, and herbal products. Bactrim and Bactrim DS are FDA-approved to treat and prevent pneumocystis https://rehabliving.net/differences-between-crack-and-cocaine-myths/ pneumonia in adults and children ages 2 months and older. Bactrim and Bactrim DS are brand-name oral tablets prescribed for certain infections.